Related links:
- Main website - https://www.gov.pl/web/ncbr
- Schedule of the Programmes in the 2023 - https://www.gov.pl/web/ncbr/harmonogram-konkursow--2023
- Detailed information - https://www.gov.pl/web/ncbr/poradnik-wnioskodawcy
NCRD-funded projects implemented at SUM:
LIDER programme
The main objective of the LIDER programme is to extend the competences of young scientists in the field of independent planning, management and leadership of their own research teams, during the implementation of scientific projects whose results can be implemented in the economy.
The LIDER programme also serves to stimulate cooperation between scientists and enterprises, providing opportunities to carry out research with commercialisation and implementation potential, activating inter-sectoral, inter-university and inter-scientific unit mobility.
The applicant applies to the programme together with a unit, which can be a research organisation (public or private) conducting research or scientific work.
Currently, SUM is implementing 1 project under the LIDER XII competition, entitled 'Development of innovative methods to improve pharmacological parameters of the pharmaceutical industry'.
Development of innovative methods to improve pharmacokinetic and pharmacodynamic parameters of selected pharmaceutically active substances (APIs)
(acronym POPPAFARM)
Project implementation time: from 01.03.2022 to 01.03.2025
Substantive project leader at SUM: Aldona Minecka, DPharm (Department of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec)
Project information:
The aim of the project is to develop alternative technologies to improve the solubility and thus increase the bioavailability of three difficult-to-solubilise Active Pharmaceutical Ingredients (APIs) belonging to groups II (bosentan, piribedil) and IV (rifaximin) of the Biopharmaceutical Classification System (BCS). Currently, the most commonly used but not always fully effective methods to improve solubility include salt formation, prodrugs, complexes, nanoemulsions or micronisation. The project plans to use three alternative pathways: amorphisation, micellization and modification of morphology and polymorphism for each APIs. Amorphous forms of the selected pharmaceuticals, including their amorphous solid dispersions (ASDs) using small- and large-molecule excipients, will be created and attempts will be made to control the morphological and polymorphic variations by, among other things, milling and compression. In addition, proprietary polymeric micellar carriers with different topologies, synthesised specifically for the properties of a given API, will be created. At the final stage, preformulations will be created using the developed technologies, for which release and solubility studies will be conducted to compare with commercially available drugs containing bosentan, rifaximin and piribedil. The project addresses the growing demand for effective, relatively simple and inexpensive methods to improve the pharmacokinetics and pharmacodynamics of difficult-to-solubilise APIs, which currently account for almost half of the available pharmaceuticals and almost 90% of substances in the research phase. The project also aims to increase the efficacy of active compounds prepared in this way, the development of targeted therapies and the economic benefits of a shortened product introduction pathway.
Link to the current competition: https://www.gov.pl/web/ncbr/lider-xiv
NUTRITECH programme - nutrition in the light of the challenges of improving societal well-being and climate change
Specific objectives of the programme:
- Implement the solutions developed (health-promoting products, nutrition plans, processes, technologies and accompanying services) to reduce the risk of chronic non-communicable diseases (including diet-related diseases).
- Implementation of developed solutions (personalised diets, health-promoting products, supporting tools, services) targeting people affected by chronic non-communicable diseases
- Implement, through the use of technological solutions, the principles of sustainability in the production and distribution processes of health-promoting foods.
- As a result of the NUTRITECH programme, Polish research units and enterprises will be supported in developing their capacity to create and use solutions based on the results of scientific research, in order to give a developmental impulse to the economy for the benefit of society in the following thematic areas:
- Nutrigenomics and biomedicine as a tool to support the fight against chronic non-communicable diseases (including diet-related diseases).
- Food in the treatment and prevention of diseases.
- Technological and economic aspects of proper nutrition.
Each of the above-mentioned areas has been defined by 3-6 issues that can become the subject of ongoing projects.
Link to the current edition of the competition: https://www.gov.pl/web/ncbr/nutritech-i-konkurs
In the first edition of the competition, for which the call ended on 12.12.2022, SUM is a consortium member in two submitted projects.
A teleinformatics system for interactive health monitoring of people with respiratory diseases in a local environment, enabling early prevention and personalised therapy
(acronym: EnviroPulmoGuard)
Project implemented as part of the Intelligent Development Operational Programme 2014-2020, co-financed by the European Regional Development Fund Priority 4: Increasing scientific and research potential, Measure 4.1: Scientific research and development work
Project duration: from 01.11.2019 to 30.06.2023
Project substantive manager at SUM: Dariusz Ziora, MD, PhD (Head of the Department of Lung Diseases and Tuberculosis, Faculty of Medical Sciences in Zabrze)
Project information:
The project aims to develop an interactive health monitoring system for people with respiratory diseases that, based on objective measurements of the patient's parameters and the environment around them, will predict and warn of impending exacerbations and indicate the need for additional doses of medication. This will make it easier to keep the disease under control, increase patients' health awareness and contribute to a person's health.
The target group will be people with respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), due to their prevalence in the population and significant impact on the health of the population.
The project will develop an experimental system including: a module for measuring the physiological parameters of the patient, a module for measuring the parameters of the local environment and a monitoring centre for collecting and processing the data of the subjects. The modules measuring environmental and physiological parameters will be worn by the patient. Encrypted data will be transmitted from them via Bluetooth to a smartphone with a special application installed, from where it will be transmitted via the GSM network to the monitoring centre. The system will be validated in a clinical setting on a selected group of patients with respiratory diseases. The data obtained will be used to develop a statistical model of the incidence of disease exacerbations depending on the monitored parameters.
Project realisers:
- Łukasiewicz Research Network - Institute of Medical Technology and Apparatus
- Medical University of Silesia in Katowice
- PUH EMAG - SERWIS Sp. z o. o.
